@generalcatalyst
Meet GC
It's been over 20 years since a human last beat a machine at chess. In cloud security, we're still putting humans against machines. Amit Megiddo co-founded Native to build security into the cloud since you can't fight AI without AI. Watch @CraneMcrane in conversation with Amit. Chapters 00:00 — Why Cloud Security Got Stuck 02:15 — Leaving AWS to Start Native 06:22 — Building the Founding Team 08:35 — Winning the First Customers 12:04 — AI Changes the Threat Landscape 15:14 — Deploying AI to Fight AI 19:32 — Earning Trust to Automate Security 24:13 — Securing Multi-Cloud Environments 35:09 — The Long-Term Vision for Native 47:58 — The Customer Explains the Problem Back
We're leading @transfyrai’s $25M seed as they come out of stealth to build the observability layer for science. Much of scientific knowledge lives in the hands and instincts of the person at the bench, and it's lost when they move on. @AnnaMarieWagner and @rwegrzyn saw this firsthand at Ginkgo Bioworks and the Advanced Research Projects Agency for Health (ARPA-H). Transfyr's physical AI captures that knowledge as it's made so scientists, models, and robots can build on it, accelerating scientific progress. Congratulations to Anna Marie, Renee, and the entire team.
Adoption of AI agents can only move at the speed of trust. We led @ArgaLabs' $10M seed as they enable teams to build that trust in testing. @PhillipLii and @akkkkiira created high-fidelity twins of the software that agents run on, so teams can watch their agent work before it is deployed to a customer.
Congratulations to @Castelion on its $1B Series C to rebuild America's advanced hypersonic weapons and other forms of deterrence. Castelion credits Blackbeard as the first American hypersonic missile engineered from inception to be mass-produced at low cost, and reports taking it from a clean sheet to a program of record in under four years. We're proud to double down on our partnership with @hargsb, Sean Pitt, Andrew Kreitz, and the entire team.
Revisit @AlexaLiautaud's full conversation with @hargsb: youtu.be/r0O1nxgq840
In 2024, we made the unprecedented decision to acquire a hospital system. It was an opportunity to create a blueprint for healthcare transformation to make American healthcare proactive, accessible, and affordable. @SummaHealth and our Health Assurance Transformation Company (HATCo) revealed their technology transformation stack, partnering with some of our portfolio companies @aidocmed, Clarium, @CommureOs, @poweredbyfabric, @hippocraticai, @judihealth, @transcarent, and @versemedical. @percepta is serving as a transformation partner, unifying the tech stack into a seamless Al-native operating system. We believe the future of healthcare is health assurance with tech founders and health system leaders working together to reimagine healthcare in the US and beyond.
"When will agents surpass humans on the internet?" @haakamaujla co-founded @agentmail to give AI agents their own email inboxes. An email address is the first thing the internet asks anyone for, and its next billion users will need one. Watch @yuris in conversation with Haakam. Chapters 00:00 — Why AI Agents Need Their Own Email 02:38 — The Drop Shipping Dream That Became AgentMail 08:27 — A Reddit Post and the First Customer 16:53 — The OpenClaw Explosion 22:31 — Email Is the Paper Trail of the Internet 29:11 — Sign In With AgentMail 32:50 — Billions of Agents in 18 Months 40:56 — Where Trust on the Internet Begins
.@river_ai_inc has a new vision for personal AI. We co-led River’s $1.1B funding round because we believe in @ibab's ambition to build open-weight models that individuals can train and improve continuously. Watch @htaneja in conversation with Igor. Chapters 02:22 — Co-Founding xAI 04:36 — An AI Experience You Own 05:59 — Betting Early on Open Weights 07:47 — How Do You Make Money on Free Models? 09:25 — Why the US Needs Its Own Open Models 11:27 — Enterprises Want to Control Their AI 13:36 — What Is Continual Learning? 16:56 — An API That Updates the Weights 19:17 — A Personal AI for Everyone 20:46 — The 20-Minute Training Run
Drug discovery is about to have its Netflix moment. @htaneja sat down with @packyM on AI flipping the economics of delivering high-efficacy drugs to tiny patient populations.
Full conversation: youtube.com/watch?v=SLnKzh…
95% of the world's internet runs through cables on the seafloor. @EndeavorSpace is moving inter-continental bandwidth to orbit. Proud to co-lead their seed round.
Read @jcfurstenberg's conversation with co-founder @chorowitz98 about how orbit is becoming infrastructure: generalcatalyst.com/stories/when-o…
"You don't want to see their hopes go up and then come crashing down. And you don't want to be the doctor behind that." @sahirjaggi founded @forus, an AI-powered network connecting doctors, pharmacies, payers, and biopharma to get medicine to patients faster. Forus exists because one in three patients prescribed a drug for a complex condition never get their first dose. Doctors steer away from the newest medicines when they can't be sure a patient will receive them, resorting to decade-old treatments. Watch @chriswbischoff in conversation with Sahir. Chapters 00:00:00 — One in Three Prescriptions Never Filled 00:02:03 — Who the Broken System Hurts Most 00:03:23 — Why Doctors Avoid Prescribing Breakthrough Drugs 00:04:58 — The Drug Discovery Boom's Hidden Bottleneck 00:06:20 — Finding the Problem Worth Solving 00:07:54 — Aligning Ten Stakeholders in a Single Prescription 00:10:52 — Going Free for Providers 00:13:25 — Cutting 90% of the Friction 00:14:23 — Winning Talent 00:19:24 — Building a Durable Network at Scale 00:25:42 — Turning Down Millions to Chase Ubiquity 00:28:20 — The Five-Year Vision Where Scientific Progress Is the Only Limit
Our space series continues. Launch costs are down more than 95% since the Shuttle era, sovereign budgets are moving at commercial speed, and a new generation of launch vehicles is reaching first flight. Welcome to the decade space stops being hard. For most of the space age, “hard” never meant the physics. It meant the one-shot problem: no do-over, a single bet built by hand, because launch was too scarce to risk anything standardized. “The most interesting builders will not limit their impact to Terra, but the possibilities of space on its own terms.” By @jcfurstenberg, @robindchnt, and @gmajczak123. Read the piece: t.co/tkcjZPqj2G
Don’t miss the first installment from our series: generalcatalyst.com/stories/space-…
“We are in a starship zipping through the cosmos. The sky is a porthole that looks out.” Physicist @carlorovelli opens our space series with his prologue, “Out There.” The further we travel into the cosmos, the closer we come to understanding our humanity here on Earth. @jcfurstenberg explains why a relentlessly ambitious vision for space begins with imagination. Explore “Out There”: t.co/504uZJd7r8
Founders gathered at the iconic Skywalker Ranch for our inaugural Founders Day: Riunione della Famiglia. @htaneja sat down with @patrickc for a fireside chat on the early days of @stripe and building an enduring company. @FareedZakaria unpacked the geopolitical moment over lunch. In the afternoon, founders traded lessons with one another, from open vs. closed models to the post-PMF valley of death. Grateful to everyone who joined us.
We first backed Dwelly in 2024, and we're energized to deepen the partnership today by co-leading its $170M Series B. Property management still runs on email and phone calls. Dwelly is buying UK letting agencies and rebuilding them from the inside with AI, cutting time-to-let by about 30% and repair times by nearly half. Our AI roll-up ambition is to reinvent the everyday services people rely on, and Dwelly is the blueprint in Europe. Congratulations to Ilia Drozdov, Dan Lifshits, @khanukov, and the entire team.
"These rent seekers who set drug prices care nothing about the patient." AJ Loiacono saw that the same drug can have 600 different prices in a month, and a $120 copay is enough to make a third of Americans skip their prescription. He built @judihealth as a single system that processes prescription and medical claims for employers, so Americans get healthcare at the right price. Watch @hollsmaloney in conversation with AJ. Chapters 00:00 — Everyone Expected Him to Be a Pharmacist 03:10 — When Drug Pricing Still Made Sense 05:46 — Your File Is Corrupted 08:50 — Raising His Ambition 13:19 — The Netflix Moment 19:23 — Same Drug, 40% More, One Mile Away 29:28 — How a $200 Chair Explains Drug Rebates 37:45 — Explaining Judi Health to a Five-Year-Old 43:37 — Never Make Money on Drug Spend 46:50 — Every Interaction Becomes a Claim 51:51 — Convincing the Board This Could Work 58:12 — A Stanford PhD Can't Decode Her Own Medical Bill
Congratulations to @chaidiscovery on its $400M Series C. Chai treats medicine design as an engineering problem, one that can be solved with precision, speed, and scale. Eli Lilly, Pfizer, and Novartis are running its generative design suite, including the latest model Chai-3, against drug targets that have defeated traditional discovery methods. We co-led Chai's Series B, and we're proud to keep backing @joshim5, @jackdent, @Mattmcpartlon1, @j_boitreaud, and the entire team.
Congratulations to @HelsingAI on its $1.8B Series E. Helsing is one of the most consequential AI companies in Europe, bringing AI-native software to defense systems. These capabilities strengthen Europe’s deterrence and enable its democratic institutions to flourish. We’re proud to deepen our partnership with @Gundbert, @torstenreil, Niklas Köhler, and the entire team.
"In what world is hurling half an F-35 at somebody an effective way to deter them?" For decades, a single hypersonic missile has cost as much as $50 million. @hargsb built SpaceX's Starshield business before founding @Castelion to make them affordable at scale, and keep America safe. Watch @AlexaLiautaud in conversation with Bryon. Chapters 00:00 — From South Georgia to Rocket Scientist 05:20 — Watching SpaceX Before Anyone Believed 08:22 — Quitting a Safe Career to Roll the Dice 13:23 — Breaking Into SpaceX 16:42 — Building Starshield and Why He Left SpaceX 22:56 — Peace Through Strength and the Case for Hypersonics 28:14 — The Hypersonics Problem No One Solved 31:10 — The SpaceX Playbook Everyone Gets Wrong 35:58 — Blackbeard's 10-Year Vision 41:50 — Who Succeeds at Castelion 49:00 — Inside the World's Largest Hypersonics Factory
We're proud to invest in @TeamOratomic's $300M Series A. Oratomic plans to build a fault-tolerant quantum computer by the end of the decade, with a simpler path to quantum error correction built on reconfigurable atomic arrays trapped in focused laser beams. This leap could fundamentally transform our world, unlocking solutions to problems like drug and materials design that are computationally impossible today. Congratulations to @DolevBluvstein and the entire team. cc: @AlexaLiautaud
"In what world is hurling half an F-35 at somebody an effective way to deter them?" For decades, a single hypersonic missile has cost as much as $50 million. @hargsb built SpaceX's Starshield business before founding @Castelion to make them affordable at scale, and keep America safe. Watch @AlexaLiautaud in conversation with Bryon. Chapters 00:00 — From South Georgia to Rocket Scientist 05:20 — Watching SpaceX Before Anyone Believed 08:22 — Quitting a Safe Career to Roll the Dice 13:23 — Breaking Into SpaceX 16:42 — Building Starshield and Why He Left 22:58 — How Castelion Got Its Name 25:34 — Peace Through Strength and the Case for Hypersonics 30:47 — The Hypersonics Problem No One Solved 33:48 — The SpaceX Playbook Everyone Gets Wrong 38:36 — Blackbeard's 10-Year Vision 44:27 — Who Succeeds at Castelion 51:38 — Inside the World's Largest Hypersonics Factory
We backed @1001ai_ at seed and are continuing to back the team in their $30M Series A. 1001 builds sovereign AI for the critical infrastructure that moves the physical world: aviation, ports, and energy. It's built and governed locally, so operators stay in control. Congratulations to @b_abughazaleh, Mohammed Fituri, and the entire team.
"We are as focused on spatial-temporal dynamics as Anthropic was on code." @gen_intuition's @PimDeWitte explains why the next frontier in AI is teaching models how the physical world unfolds in time. These world models unlock robotics, simulation, and scientific discovery. Congratulations to Pim and the team on their Series A. We’re proud to keep backing them. Revisit @max_rimpel's full conversation with Pim below.
Full conversation: youtube.com/watch?v=xk9o-O…
"The fintechs wanted to remove the friction, and hence remove the advisor. But that friction was passed down to the end client." For over a decade, the promise was that tech would replace the financial advisor. Instead, all the complexity and anxiety got handed to the customer. @rronrex founded @arca_wealth to fix that. AI handles the back-office work so advisors can focus on clients and help them reach their full financial potential. We're proud to lead Arca's Series A. Congratulations to Rron and the entire Arca team. Watch @Natlevywesthead's full conversation with Rron. Chapters 00:00 — Where the Trust Began 01:21 — Kosovo to America 02:47 — Lessons from Cadre and Plaid 05:25 — It's Not About the Money 09:16 — The Two Decisions That Change Everything 13:22 — The Millions Nobody Serves 15:48 — Inside Arca 17:25 — Why AI Shouldn't Replace Your Advisor 19:54 — The Cockpit Every Advisor Wants 23:27 — What the AI Does Behind the Scenes 29:54 — AI Services vs. AI Software 34:38 — What a Restaurant Taught a Fintech 38:59 — Hiring People Who'll Outgrow You 51:41 — Becoming Your Financial Everything
Why we invested by Alex Tran & @Natlevywesthead: generalcatalyst.com/stories/our-in…
Through its agreement to be acquired by @Qualcomm, @Modular aims to accelerate its mission and real-world impact by empowering developers everywhere with production-grade AI software. Congratulations to @clattner_llvm, @iamtimdavis, and the extended Modular team on their journey to make AI’s compute layer unified, efficient, and accessible to all.
"Even if your sole mission was to make ChatGPT the best model possible for you, your efforts would be pretty much futile. The next generation comes and washes out all the context engineering and sticky notes you prepared." Every AI model starts each conversation from scratch, re-reading the same files and seeing only sticky notes about you and your work. @dan_biderman left academia to build @EngramLab so AI can truly remember your world. We've backed Engram since its first round and are proud to support its $98M launch out of stealth. Congratulations to Dan, @EyubogluSabri, @jxmnop, @realJessyLin, @scott_linderman, Chris Ré, and the Engram team. Watch @marcbhargava's full conversation with Dan. 00:00 — Meet Dan and the Engram Story 00:25 — From Studying Brains to Building Them 02:10 — Building the Founding Team 05:20 — Why Every AI Model Starts From Scratch 07:44 — Building a Product in a Few Months 11:39 — Cutting Inference Tokens 10–100x 13:51 — The Quality Payoff Beyond Cost Savings 15:43 — Why This Couldn't Have Worked a Year Ago 18:22 — Distilling All of Microsoft and Slack Into a Brain 21:40 — Partnering With Giants as a Months-Old Startup 23:39 — The Self-Serve Bet in a Forward-Deployed World 33:44 — Models That Learn Like a Tamagotchi 34:44 — What Keeps Him Up at Night
Why we invested by @marcbhargava & @max_rimpel: generalcatalyst.com/stories/our-in…
"Bad ideas that turn good is where the alpha is." Nearly every investor told @l3amm usage-based billing was a terrible idea, and he built @getmetronome anyway. They saw what others couldn’t at exactly the right time. Metronome became the billing system behind some of the biggest names in AI, and @stripe acquired it earlier this year. Watch GC's @quentinclark in conversation with Scott. Chapters 00:00 — Meeting Scott at Dropbox 01:36 — Why Speed and Correctness Go Together 04:18 — Billing Was the Intern Project 06:09 — Betting Half of Software Goes Usage-Based 10:51 — Rejection Road Trip 12:24 — The Only Term Sheet They Got 16:44 — Refusing to Ship a Wrong Invoice 22:24 — Becoming CEO Overnight 27:06 — When Usage Went Exponential 31:45 — Choosing Customers Who Set the Bar 36:50 — Answering the Stripe Call
“If the technology that helps us be competitive in manufacturing comes from an adversarial country, we have a serious problem.” @standardbots is building the robots that bring American manufacturing back, designed so any worker can train them. We’re proud to double down on
The momentum of @AnthropicAI is generational. Grateful to be part of this journey. Onward.
Announcing @AnthropicAI's $65B Series H raise.
"There is no truth out there. If the truth is out there, you wouldn't reinvent things or think about things differently." That mindset led @maltekosub and @o_stefan to build @parloa_ai on voice when everyone said chat would change everything, and to turn down $7.7M to keep
.@htaneja and @jcfurstenberg have been named to the @Forbes Midas List this year, Hemant for the 10th consecutive year. We exist to back founders working on the big, right problems and to build a company worthy of their ambition. From @AnthropicAI, @AppliedInt, and @deel to
Full list: forbes.com/lists/midas/
“The digital world lacks physical information. The physical world lacks dense digital information. Games perfectly merge these two together, and we believe that’s just the next phase of pretraining.” Every few weeks @gen_intuition ships new emergent capabilities that are
Meet GC
"Our collective, sector wide ambition is being constrained by our own behavior.” @htaneja's inaugural quarterly review is a reflection on building the AI era with our souls intact. It explores @percepta's LLM-as-computer breakthrough, the Customer Value Fund reaching investment
Q1 review in full: hemant-taneja.com
“If we’re going to bend the cost curve in healthcare and change the way people access care, we need to reimagine things from first principles. That’s what got us to where we are today: we’re an operating system for health plans.” We are leading @YuzuHealthInc's $35M Series A to
Navy submarine officer turned founder @CameronLMcCord: "When you're 484 days underwater, you need to feel motivated and understand how what you're doing plays into a bigger picture. That's something I always try to do at @Nominal_io." The bigger picture is global resilience.
.@maitreya_wagh and @xan_ps watched voice AI demos work perfectly in labs, then break in Mumbai call centers: customers code-switching mid-sentence, connections dropping, reality exposing every edge case. They'd seen this pattern before—Maitreya shipping products at Datamuni and
When we led @StillaAI’s seed round, we backed founders who’ve been building together for over a decade and know what it means to ship products at hyperscale. @siavashg and @kajdro scaled Shop and Shop Pay at Shopify to hundreds of millions of users. They learned that velocity is
Healthcare's AI transformation is accelerating, and JPM 2026 made that clear. We kicked off the week with our second annual Healthcare CEO Dinner, co-hosted by our CEO @htaneja alongside Matt Garman, CEO of @awscloud, bringing together the founders, investors, and executives
.@maltekosub started building conversational interfaces in 2016 when the market was full of chatbots that looked great in demos but broke in production. He saw something others didn't: voice—not chat—would be where enterprises needed AI most. He teamed up with @o_stefan to make
.@SaketRKumar is a builder at heart and @rishabhjain1198 engineered Grok at xAI. They met in March 2025 and launched @PrimeMeridianAI four months later—100% on TaxCalcBench, live for tax season. We've known Saket since 2017, when he was at La Famiglia, which became part of
